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Protective effects of 17 beta-estradiol on endothelial function injured by oxidized low-density lipoproteins
Aim:
To test the protective effects of 17 beta-estradiol against endothelial cell damages due to oxidized low-density lipoproteins (LDL) and lysophosphatidylcholine (LPC), a principal component of oxidized LDL.
Methods:
After the tension was increased by phenylephrine, the effects of oxidized LDL or LPC on the vasorelaxation responses to acetylcholine (ACh) were investigated in the isolated rabbit thoracic aortas.
Results:
17 beta-Estradiol attenuated the inhibition of vasorelaxation responses to ACh by oxidized LDL or LPC in a concentration-dependent manner. However, the protective effect of 17 beta-estradiol was partially attenuated by indometacin (10 mumol.L-1), a cyclooxygenase inhibitor.
Conclusion:
17 beta-Estradiol possesses protective effects on the endothelium against injury elicited by oxidized LDL or LPC, which may be related to its stimulation of epoprostenol production.