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Complex effects of general anesthesia on sensory processing in the spinal dorsal horn
T Yanagidani1, K Ota, J G Collins
1Department of Anesthesiology, Yale University, 333 Cedar St., P.O. Box 208051, New Haven, CT 06520-8051, USA.
Brain Research
|November 14, 1998
Abstract:
A chronic animal preparation allowed us to compare activity of the same single, spinal dorsal horn neurons in the physiologically intact, awake, drug-free state and in the anesthetized state. The inhalation anesthetic enflurane produced profound, and at times, opposite effects on spinal dorsal horn neuron responses to non-noxious and noxious receptive field stimulation. Some effects would not have been predicted, based upon current understanding of anesthetics.