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[Primary gastritis associated with Helicobacter pylori in children]
1Disciplina de Gastroenterologia Pediátrica, Universidade Federal de São Paulo-Escola Paulista de Medicina-UNIFESP-EPM, SP.
Insights
This study found no significant link between Helicobacter pylori infection and dyspeptic symptoms in children. Antral nodularity was common, but symptom relief after treatment was not statistically significant.
Area of Science:
- Pediatric Gastroenterology
- Infectious Diseases
Background:
- Dyspeptic symptoms are common in children.
- Helicobacter pylori infection is a potential cause of gastric inflammation.
- Establishing a direct correlation between H. pylori and dyspeptic symptoms requires robust evidence.
Purpose of the Study:
- To investigate the correlation between dyspeptic symptoms and Helicobacter pylori infection in pediatric patients.
- To evaluate the impact of H. pylori eradication therapy on symptoms and endoscopic findings.
Main Methods:
- Prospective study of 27 children with H. pylori-associated antral gastritis.
- Diagnosis confirmed by rapid urease test and histology.
- Endoscopic and histological assessments before and after antimicrobial therapy.
Main Results:
- Antral nodularity observed in 74% of patients; active chronic superficial gastritis in 96%.
- H. pylori eradication achieved in 8/27 patients.
- Symptom remission occurred in 4/8 eradicated patients and 8/19 non-eradicated patients.
- No statistically significant correlation found between H. pylori eradication and symptom remission.
Conclusions:
- Antral nodularity is a frequent endoscopic finding in pediatric H. pylori gastritis.
- This study did not find sufficient evidence to support a correlation between H. pylori infection and dyspeptic symptoms in children.
- Further research may be needed to clarify the complex relationship between H. pylori, gastric changes, and symptoms.
Abstract:
The aim of this paper was to investigate whether a correlation between dyspeptic symptoms and infection due to Helicobacter pylori could be established. We conducted a prospective study with 27 children who had Helicobacter pylori associated antral gastritis with endoscopic and histologic alterations, without any other peptic lesions. Helicobacter pylori was detected by rapid urease test and histology with hematoxylin and eosin and Giemsa stain. Endoscopy revealed antral nodularities in 20/27 (74%) and enantema in six cases (23%). During histological examination active chronic superficial gastritis was confirmed in 26 cases (96%). Twenty seven children were treated with antimicrobial therapy, eight of which presented infection eradication, six presented nodularities regression and symptoms remission in four. Of the 19 non-eradicated patients, eight (42%) became asymptomatic and 11 maintained symptoms. Statistical analysis to compare symptoms remission was not significant. Taking into account the results presented herewith, we concluded that antral nodularity was the most common endoscopic finding, and there was no sufficient evidence of a correlation between Helicobacter pylori infection and dyspeptic symptoms.