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Related Experiment Videos

Which androgen replacement therapy for women?

H M Buckler1, W R Robertson, F C Wu

  • 1Department of Endocrinology and Medicine, University of Manchester, Hope Hospital, Salford, United Kingdom.

The Journal of Clinical Endocrinology and Metabolism
|November 14, 1998
PubMed
Summary
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This study compared testosterone (T) delivery methods for postmenopausal women. A new transdermal system provided stable, physiological T levels, unlike oral or implant methods, suggesting its value for androgen therapy.

Area of Science:

  • Endocrinology
  • Pharmacokinetics
  • Women's Health

Background:

  • Postmenopausal women experience declining androgen levels, impacting well-being.
  • Androgen replacement therapy (ART) is increasingly considered for select postmenopausal women.
  • Existing testosterone (T) preparations have limitations in delivery and physiological relevance.

Purpose of the Study:

  • To compare the pharmacokinetics of oral testosterone undecanoate (TU), subcutaneous (sc) T implants, and a novel transdermal T delivery system.
  • To evaluate the suitability of these T preparations for androgen replacement therapy in postmenopausal women.

Main Methods:

  • Study 1: Oral TU pharmacokinetics in 10 postmenopausal women across three doses.
  • Study 2: Pharmacokinetics of sc T implants versus placebo in 30 women on estradiol therapy.

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  • Study 3: Pharmacokinetics of a novel matrix transdermal T system (TD1, TD2, TD3) in 6 females.

    • Main Results:

    • Oral TU showed highly variable and unpredictable T absorption.
    • Subcutaneous T implants resulted in unphysiological T levels for 1-2 months.
    • The novel transdermal system demonstrated stable T levels with minimal within- and between-subject variation.

    Conclusions:

    • Oral TU is unsuitable for women due to unpredictable absorption and wide T level fluctuations.
    • Subcutaneous T implants yield unphysiological T levels.
    • The matrix transdermal T delivery system offers a reliable, controllable, and non-invasive method for achieving physiological T levels in postmenopausal women.