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Related Experiment Videos

Chronic angioedema. Three relevant cases

A Sánchez Palacios1, F Schamann Medina, J A García Marrero

  • 1Allergy Unity, Hospital Insular, Las Palmas de Gran Canaria, Spain.

Allergologia Et Immunopathologia
|November 17, 1998
PubMed
Summary
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Complement disorders can cause severe angioedema, including laryngeal edema. Early diagnosis and treatment with antifibrinolytic agents or danazol/stanazolol lead to favorable outcomes, avoiding antihistamines or steroids.

Area of Science:

  • Immunology
  • Complement System
  • Vascular Biology

Background:

  • Angioedema is a swelling of the deep layers of skin and submucosa.
  • Complement system disorders can manifest as angioedema.
  • Diagnosis can be challenging, especially without a family history.

Observation:

  • Three cases of angioedema with complement abnormalities are presented.
  • Patients exhibited functional C1 inhibitor deficit, low CH50, or reduced C1q, C3, C4.
  • Symptoms included severe laryngeal edema in two patients.

Findings:

  • Complement disorders are implicated in the pathogenesis of angioedema.
  • Antifibrinolytic agents (epsilon-aminocaproic acid, tranexamic acid) and androgens (danazol, stanazolol) are effective treatments.

Related Experiment Videos

  • Antihistamines and steroids were not effective.

    • Implications:

    • Correct diagnosis of complement disorders is crucial for effective angioedema management.
    • Targeted therapies can prevent severe complications like laryngeal edema.
    • Understanding complement pathways offers new therapeutic avenues for angioedema.