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Related Experiment Videos

Urinary IL-6 is elevated in patients with urolithiasis

E Rhee1, L Santiago, E Park

  • 1Department of Urology, Southern California Permanente Medical Group, Los Angeles, USA.

The Journal of Urology
|November 17, 1998
PubMed
Summary

Patients with urolithiasis (kidney stones) show elevated levels of interleukin-6 (IL-6), a cytokine. This IL-6 elevation in stone disease is distinct from infection-related cytokine changes, suggesting a potential role in stone formation.

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Area of Science:

  • Urology
  • Immunology
  • Biochemistry

Background:

  • Urolithiasis, or kidney stone disease, affects a significant portion of the population.
  • The role of inflammatory cytokines in the pathogenesis of urolithiasis is not fully understood.
  • Interleukins (IL) are key mediators of inflammation, and their urinary levels may provide insights into stone disease.

Purpose of the Study:

  • To investigate the potential role of specific cytokines, namely interleukin-1 beta (IL-1beta), interleukin-1 alpha (IL-1alpha), and interleukin-6 (IL-6), in patients diagnosed with urolithiasis.
  • To differentiate cytokine profiles in patients with kidney stones from those with bacterial cystitis and healthy individuals.

Main Methods:

  • Enzyme immunoassays were employed to quantify urinary levels of IL-1alpha, IL-1beta, and IL-6.

Related Experiment Videos

  • Urine samples were collected from three groups: 56 patients with current stone disease, 63 patients with bacterial cystitis, and 66 healthy controls.
  • Statistical analysis included the Kruskal-Wallis test, Newman-Keuls test, and chi-squared test to compare cytokine levels across groups.

    • Main Results:

    • Patients with urolithiasis exhibited significantly elevated urinary IL-6 levels compared to normal subjects (p < 10(-7)).
    • Urinary IL-1beta and IL-1alpha levels were not significantly different between stone patients and normal subjects.
    • Bacterial cystitis patients showed significant elevations in all three cytokines (IL-1alpha, IL-1beta, and IL-6) relative to normal subjects, with IL-6 levels lower than in stone patients.

    Conclusions:

    • Urolithiasis patients demonstrate a distinct elevation in urinary IL-6, independent of bacterial infection.
    • The observed IL-6 elevation in stone disease differs from the cytokine profile seen in bacterial cystitis.
    • Elevated IL-6 may contribute to the understanding of urolithiasis pathogenesis and could serve as a potential diagnostic marker for kidney stone disease.