Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Type I interferons: expression and signalization

J Doly1, A Civas, S Navarro

  • 1UPR 37, CNRS, UFR Biomédicale Paris V, France. Janine.Doly@biomedicale.univ-paris5.fr

Cellular and Molecular Life Sciences : CMLS
|November 18, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prediction of Mutations and Outcome in Gastrointestinal Stromal Tumors with Deep Learning: A Multicenter, Multinational Study.

medRxiv : the preprint server for health sciences·2026
Same author

Digital image analysis workflows for evaluation of cell behavior and tumor microenvironment to aid therapeutic assessment in high-risk neuroblastoma.

Computers in biology and medicine·2023
Same author

Dyskeratosis congenita: natural history of the disease through the study of a cohort of patients diagnosed in childhood.

Frontiers in pediatrics·2023
Same author

The sound of a Martian dust devil.

Nature communications·2022
Same author

[Sepsis Code: dodging mortality in a tertiary hospital].

Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia·2021
Same author

The Mars Environmental Dynamics Analyzer, MEDA. A Suite of Environmental Sensors for the Mars 2020 Mission.

Space science reviews·2021
Same journal

Elektra-Qki and Alien-Wt1 lncRNA-protein interaction controls myocardial ion channel expression and epicardial EMT during heart development in mice.

Cellular and molecular life sciences : CMLS·2026
Same journal

SHIP1 is required for T cell surveillance of occult malignancies.

Cellular and molecular life sciences : CMLS·2026
Same journal

Reply to: Commentary on "The food additive 4-hexylresorcinol impairs intestinal stem cell function and exacerbates inflammatory bowel disease in Drosophila melanogaster via suppression of MAPK signaling pathway".

Cellular and molecular life sciences : CMLS·2026
Same journal

The BmCPV-derived viral small peptide vsp1S4(-) suppresses viral replication by triggering apoptosis via the ROS-JNK signalling pathway.

Cellular and molecular life sciences : CMLS·2026
Same journal

UBE2L6 promotes invasion and metastasis of triple-negative breast cancer by enhancing autophagy through STK38 ISGylation.

Cellular and molecular life sciences : CMLS·2026
Same journal

Inhibition of ferroptosis via SLC25A39-NRF2 axis drives Osimertinib resistance in lung adenocarcinoma.

Cellular and molecular life sciences : CMLS·2026
See all related articles

Type I interferons (IFN-A and IFN-B) are crucial for antiviral defense and immune response. This review examines the regulatory factors controlling their gene expression and signal transduction pathways.

Area of Science:

  • Immunology
  • Molecular Biology
  • Virology

Background:

  • Type I interferons (IFN-A and IFN-B) are key cytokines with roles in antiviral defense, immune activation, and cell growth regulation.
  • Their therapeutic potential is established for viral and malignant diseases.
  • Virus infection triggers a two-step pathway involving IFN gene induction and subsequent transcriptional activation of numerous genes.

Purpose of the Study:

  • To review factors controlling Type I interferon gene expression.
  • To understand mechanisms of IFN gene induction and repression.
  • To elucidate cytokine properties via signal transduction pathways.

Main Methods:

  • Literature review of studies on interferon regulatory factors and IFN-stimulated genes (ISGs).

Related Experiment Videos

  • Analysis of transcriptional regulation of IFN-A gene families.
  • Examination of signal transduction pathways.

    • Main Results:

    • Type I IFNs are induced by virus infection, initiating an antiviral response.
    • IFN-A and IFN-B gene expression involves common regulatory factors but shows cell-type specific transcriptional activity.
    • Differences in individual IFN-A mRNA expression reflect promoter activity.

    Conclusions:

    • While significant progress has been made, some factors regulating Type I IFN-A gene expression remain unidentified.
    • Understanding these factors is crucial for explaining IFN properties and therapeutic applications.
    • Further research is needed to fully elucidate the complex regulatory network of Type I IFNs.