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Effect of intraluminal temperature on human oesophageal motor function
O Ozdoğan1, A J Saadalla, G Emironal
1Department of Medicine, Marmara University School of Medicine, Istanbul, Turkey.
Clinical Physiology (Oxford, England)
|November 18, 1998
Summary
Cold intraluminal temperature significantly alters oesophageal motor activity, prolonging sphincter relaxation and contraction duration. These effects of cooling the oesophageal lumen are not adaptive.
Area of Science:
- Gastroenterology
- Physiology
Background:
- Oesophageal motor activity is influenced by bolus temperature.
- Detailed documentation of sustained cold or warm intraluminal temperature effects on oesophageal motility is lacking.
Purpose of the Study:
- To investigate the effects of sustained cold and warm intraluminal temperatures on oesophageal motor activity in normal subjects.
Main Methods:
- Oesophageal manometry was conducted on 11 healthy individuals.
- Intraluminal temperatures were applied: room (34.2°C), cold (30.6°C), and warm (39.7°C).
Main Results:
- Low-temperature treatment prolonged lower oesophageal sphincter relaxation and oesophageal peristaltic contraction duration.
- Cooling attenuated contraction pressure slope and increased non-transmitted/simultaneous contractions.
- Effects of low temperature were constant, showing no adaptation.
Conclusions:
- Cooling the oesophageal lumen alters motor activity.
- The observed effects of low-temperature application on oesophageal motility are non-adaptive.