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Technological advances in high-throughput screening

P B Fernandes1

  • 1Small Molecule Therapeutics Inc., Monmouth Junction, NJ 08852, USA. fernandes@smtherapeutics.com

Current Opinion in Chemical Biology
|November 18, 1998
PubMed
Summary
This summary is machine-generated.

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Advancements in high-throughput screening (HTS) utilize diverse assay technologies, including cell-based and cell-free systems. Innovations in engineering and chemistry enable ultra-high-throughput screening for drug discovery and target identification.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Assay Development

Background:

  • High-throughput screening (HTS) is crucial for drug discovery and biological research.
  • Continuous development of novel assay technologies is essential for advancing screening capabilities.

Purpose of the Study:

  • To review and summarize the latest developments in assay technologies for high-throughput screening.
  • To highlight innovations enabling ultra-high-throughput screening and target identification.

Main Methods:

  • Overview of various assay formats including cell-based, microbial, and cell-free systems.
  • Discussion of advanced detection techniques like time-resolved fluorescence and single molecule fluorescence.
  • Exploration of engineering and chemistry innovations for miniaturized assay volumes (nanoliter and picoliter).

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Main Results:

  • A wide array of assay technologies are available, catering to different interaction types (nucleic acid-protein, receptor-ligand).
  • Cell-free homogeneous assay systems have been modified for enhanced performance.
  • Nanoliter and picoliter volume delivery systems and sensitive biosensors facilitate ultra-high-throughput screening.

Conclusions:

  • Ongoing technological advancements are expanding the scope and efficiency of high-throughput screening.
  • Integration of genomic information with screening technologies is paving the way for next-generation drug discovery.
  • Future screens will benefit from sensitive detection methods and miniaturized assay formats.