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Antimicrobial activity of the semisynthetic compound, hexahydrocolupulone
T E Stephan1, E O Ngo, P Ferrieri
1Department of Pharmacology, University of Minnesota Medical School, Minneapolis 55455, USA.
The Journal of Antimicrobial Chemotherapy
|November 18, 1998
Abstract:
In this study we demonstrate that hexahydrocolupulone (HHC) more effectively inhibits the growth in vitro of Gram-positive organisms than Mycobacterium tuberculosis or Escherichia coli. Vancomycin-resistant Enterococcus faecium, methicillin-resistant Staphylococcus aureus, and coagulase-negative staphylococci were inhibited by HHC at concentrations < or = 4.06 mg/L. Growth inhibition profiles varied according to the microorganism evaluated (static for S. aureus and bactericidal for Bacillus subtilis).