Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Polymyositis: response to vitamin E

R N Killeen, S Ayres, R Mihan

    Southern Medical Journal
    |October 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    A polymyositis patient experienced severe decline despite immunosuppressants. High-dose vitamin E (d, alpha-tocopheryl acetate) supplementation led to a remarkable recovery, suggesting its therapeutic potential.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Psychotic disorders in young adults with perinatally acquired HIV: a UK case series.

    Psychological medicine·2020
    Same author

    Non-viral transfection of goat germline stem cells by nucleofection results in production of transgenic sperm after germ cell transplantation.

    Molecular reproduction and development·2012
    Same author

    Keratosis palmaris et plantaris.

    Archives of dermatology and syphilology·2010
    Same author

    Generalized moniliasis and trichophytosis.

    Archives of dermatology and syphilology·2010
    Same author

    Adenoma sebaceum.

    Archives of dermatology and syphilology·2010
    Same author

    Congenital ectodermal defect.

    Archives of dermatology and syphilology·2010
    Same journal

    SMA's 6th Annual Physicians-in-Training Leadership Conference Abstract Presentations.

    Southern medical journal·2026
    Same journal

    Potential Impact of Lower Federal Loan Availability on Medical Education in Appalachia.

    Southern medical journal·2026
    Same journal

    Experiential Mentorship Skills Training: The Effect on Real-Life Mentoring.

    Southern medical journal·2026
    Same journal

    Social Pressure: How Early Social Context Shapes Career Interest in Medicine.

    Southern medical journal·2026
    Same journal

    Comparing Speed and Accuracy of Artificial Intelligence Large Language Models on the Orthopedic In-Training Examination.

    Southern medical journal·2026
    Same journal

    Don't Wait to Talk about Weight: A 2-Hour Interactive Curriculum Improves Medical Student Skills with Weight Management.

    Southern medical journal·2026
    See all related articles

    Area of Science:

    • Neurology
    • Immunology
    • Nutritional Science

    Background:

    • Polymyositis is an idiopathic inflammatory myopathy.
    • Standard immunosuppressive therapies can be ineffective or lead to deterioration.
    • The role of oxidative stress in inflammatory myopathies is increasingly recognized.

    Purpose of the Study:

    • To report a case of polymyositis refractory to standard treatment.
    • To investigate the potential therapeutic effect of vitamin E in polymyositis.
    • To discuss the underlying mechanisms and rationale for vitamin E use.

    Main Methods:

    • A 70-year-old female patient with polymyositis was treated with three different immunosuppressive drugs.
    • The patient's clinical status was monitored over a three-month period.

    Related Experiment Videos

  • High-dose vitamin E (d, alpha-tocopheryl acetate) was administered following disease progression.

    • Main Results:

    • The patient's condition significantly worsened on immunosuppressive therapy, leading to complete helplessness.
    • Administration of high-dose vitamin E resulted in a dramatic and rapid clinical improvement.
    • No adverse effects were reported during vitamin E supplementation.

    Conclusions:

    • Vitamin E (d, alpha-tocopheryl acetate) may represent a promising therapeutic option for refractory polymyositis.
    • The antioxidant properties of vitamin E could counteract oxidative stress implicated in polymyositis pathogenesis.
    • Further research is warranted to confirm the efficacy and safety of vitamin E in larger polymyositis cohorts.