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Henoch Schönlein purpura and amebiasis
G Demircin1, A Oner, O Erdoğan
1Department of Nephrology, Dr Sami Ulus Children's Hospital, Ankara, Turkey.
Acta Paediatrica Japonica : Overseas Edition
|November 20, 1998
Summary
Henoch Schönlein purpura (HSP) is an immune complex disease. This case report details a potential link between HSP and Entamoeba histolytica infection in an 11-year-old boy.
Area of Science:
- Pediatrics
- Infectious Diseases
- Nephrology
Background:
- Henoch Schönlein purpura (HSP) pathogenesis is often linked to immune complex reactions triggered by infections.
- The association between HSP and Entamoeba histolytica has not been previously documented.
Observation:
- An 11-year-old boy presented with clinical and biopsy-confirmed HSP, including leukocytoclastic vasculitis and glomerulonephritis with IgA and C3 deposition.
- Entamoeba histolytica cysts and trophozoites were identified in the patient's stool concurrently with HSP symptoms.
Findings:
- Successful treatment of Entamoeba histolytica with metronidazole led to the disappearance of the parasite from stool samples.
- The study highlights a potential temporal association between Entamoeba histolytica infection and the onset of HSP.
Implications:
- This case suggests a possible causal relationship or significant association between Entamoeba histolytica and Henoch Schönlein purpura.
- Further research is warranted to explore the role of Entamoeba histolytica as a potential antigenic stimulus in HSP pathogenesis.