Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Oxidative DNA base modifications as factors in carcinogenesis

R Olinski1, P Jaruga, T H Zastawny

  • 1Department of Clinical Biochemistry, The Ludwik Rydygier Medical University in Bydgoszcz, Poland. ryszardo@aci.amb.bydgoszcz.pl

Acta Biochimica Polonica
|November 20, 1998
PubMed
Summary

Reactive oxygen species cause DNA base damage, increasing cancer risk. Cancer therapies can induce this damage, potentially leading to secondary cancers like leukemia.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Structural, electronic and energetic consequences of epigenetic cytosine modifications.

Physical chemistry chemical physics : PCCP·2015
Same author

Measurement of oxidatively induced DNA damage and its repair, by mass spectrometric techniques.

Free radical research·2015
Same author

Salt shield: intracellular salts provide cellular protection against ionizing radiation in the halophilic archaeon, Halobacterium salinarum NRC-1.

Environmental microbiology·2009
Same author

The role of CSA in the response to oxidative DNA damage in human cells.

Oncogene·2007
Same author

Modulation of oxidative DNA damage repair by the diet, inflammation and neoplastic transformation.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society·2007
Same author

A genomic view of the sea urchin nervous system.

Developmental biology·2006

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • Reactive oxygen species (ROS) induce DNA modifications, including premutagenic base damage.
  • Unrepaired DNA base damage is implicated in carcinogenesis.
  • Elevated modified bases are observed in cancerous and precancerous tissues.

Purpose of the Study:

  • To investigate the impact of anticancer therapies on DNA base modifications.
  • To explore the role of oxidative base damage in cancer initiation and progression.

Main Methods:

  • Analysis of DNA base modifications in lymphocytes from cancer patients.
  • Assessment of damage induced by ionizing radiation and anticancer drugs.

Main Results:

Related Experiment Videos

  • Therapeutic doses of ionizing radiation and anticancer drugs cause DNA base modifications in patient lymphocytes.
  • Identified base damages have the potential to cause mutagenesis in critical genes.
  • Increased modified base products may contribute to genetic instability and tumor metastasis.

    • Conclusions:

    • Oxidative base damage plays a significant role in cancer initiation.
    • Therapy-induced DNA damage may lead to secondary malignancies, such as leukemias.
    • Elevated modified bases can enhance tumor genetic instability and metastatic potential.