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Cytomegalovirus iritis

L Cheng¹, N A Rao, K S Keefe

¹Department of Ophthalmology, Shiley Eye Center, University of California, San Diego 92093-0946, USA.

Ophthalmic Surgery and Lasers

|November 24, 1998

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Cytomegalovirus (CMV) can directly cause iritis, inflammation of the iris, in patients with acquired immunodeficiency syndrome (AIDS). Autopsy confirmed CMV as the cause of iritis in an AIDS patient with CMV retinitis.

Area of Science:

Ophthalmology
Virology
Immunology

Background:

Cytomegalovirus (CMV) is a common opportunistic pathogen in individuals with acquired immunodeficiency syndrome (AIDS).
CMV commonly causes retinitis in AIDS patients, but its role in iritis is less understood.
This case investigates a potential direct link between CMV infection and iritis in an immunocompromised patient.

Observation:

A patient diagnosed with acquired immunodeficiency syndrome (AIDS) presented with cytomegalovirus (CMV) retinitis.
Histological examination of the patient's left eye post-mortem revealed focal iritis.
The iritis exhibited infiltration of acute inflammatory cells alongside characteristic cytomegalic cells.

Findings:

CMV-specific immunohistochemical staining confirmed the presence of cytomegalovirus within the inflamed iris tissue.

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The histological findings strongly suggest that CMV was the direct cause of the focal iritis.

This case provides direct evidence of CMV as a causative agent of infectious iritis.

Implications:

The findings suggest CMV should be considered a direct cause of infectious iritis in the context of AIDS.
This highlights the importance of considering ocular manifestations beyond retinitis in CMV-infected AIDS patients.
Further research may elucidate the mechanisms and prevalence of CMV-induced iritis in immunocompromised populations.