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Updated: Aug 13, 2026

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ADP-ribosylation factors in rat parotid acinar cells
Y Dohke1, M Hara-Yokoyama, J Fujita-Yoshigaki
1Dept. Physiology, Nihon University School of Dentistry at Matsudo, Chiba, Japan.
Abstract:
ADP-ribosylation factor (Arf) is a 20 kDa polypeptide that is a member of the Ras superfamily of small molecular mass GTP-binding proteins. In addition to an essential role of Arf1 in vesicle budding, recent observations suggest a role for Arf6 in calcium-dependent exocytosis in bovine adrenal chromaffin cells. In rat parotid acinar cells, exocytosis is cAMP-dependent and our findings suggest an interaction of Arf1 with the secretory granules. We describe here the structural and functional background to the Arf proteins focusing on their role in rat parotid acinar cells.
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