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[The protective effect of the nerve growth factor in exposing a nerve tissue culture to diphtheria toxin]
N I Chalisova1, G N Akoev, V A Penniiaĭnen
1Pavlov Institute of Physiology, RAS, St. Petersburg.
Morfologiia (Saint Petersburg, Russia)
|November 25, 1998
Abstract:
Diphtheria toxin (1.10(-1)-1.10(-6) Lf/ml) was found to inhibit neurite extension in chick embryo dorsal root ganglia in vitro. If the nerve growth factor (60 ng/ml) was added with toxin in culture media the diphtheria toxin effect was decreased and the neurite outgrowth was compared with control. Protective effect of nerve growth factor by influence of diphtheria toxin may be used in new principles of diphtheria treatment.