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Related Experiment Videos

Metastatic tumor thrombus attached to a pacemaker electrode

H Tada1, K Asazuma, H Naiki

  • 1Third Department of Internal Medicine, Fukui Medical School, Japan.

Pacing and Clinical Electrophysiology : PACE
|November 25, 1998
PubMed
Summary

A pacemaker electrode facilitated a large tumor embolus, causing pulmonary emboli. This rare complication stemmed from squamous cell carcinoma originating in the esophagus.

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Area of Science:

  • Cardiology
  • Oncology
  • Pathology

Background:

  • Pacemaker implantation is a common procedure for cardiac rhythm management.
  • Tumor emboli are a rare but serious complication, often associated with advanced malignancies.
  • Esophageal cancer can metastasize through various routes, including hematogenous spread.

Observation:

  • A postmortem examination revealed a large tumor embolus attached to a pacemaker electrode.
  • The embolus was composed of well-differentiated squamous cell carcinoma and fibrin.
  • Multiple pulmonary emboli were identified, originating from the tumor embolus.

Findings:

  • The patient had a primary squamous cell carcinoma in the lower intrathoracic esophagus.
  • The tumor embolus was found to be localized to the pacemaker electrode, with no direct cardiac tissue invasion.

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  • Turbulent blood flow around the pacemaker electrode likely contributed to the accumulation of tumor microemboli.

    • Implications:

    • This case highlights a unique mechanism of tumor embolization facilitated by a medical device.
    • It underscores the importance of considering unusual metastatic pathways in patients with pacemakers and malignancy.
    • Further research may explore the role of indwelling devices in cancer progression and metastasis.