Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Defining multiple sclerosis disease activity using MRI T2-weighted difference imaging

M A Lee1, S Smith, J Palace

  • 1Centre for Functional Magnetic Resonance Imaging of the Brain, John Radcliffe Hospital, Headington, UK.

Brain : a Journal of Neurology
|November 25, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Activation of TREK-1 and TREK-2 Two-Pore Domain Potassium Channels by the K<sub>v</sub>4 Channel Modulator, NS5806.

Pharmacology research & perspectives·2026
Same author

Pan-Asian adapted ESMO Clinical Practice Guidelines for the diagnosis, treatment and follow-up of patients with pancreatic cancer.

ESMO open·2025
Same author

Pan-Asian adapted ESMO Clinical Practice Guidelines for the diagnosis, treatment and follow-up of patients with metastatic colorectal cancer.

ESMO open·2023
Same author

The use of OCT in good visual acuity MOGAD and AQP4-NMOSD patients; with and without optic neuritis.

Multiple sclerosis journal - experimental, translational and clinical·2022
Same author

Pan-Asian adapted ESMO Clinical Practice Guidelines for the diagnosis treatment and follow-up of patients with localised colon cancer.

Annals of oncology : official journal of the European Society for Medical Oncology·2021
Same author

Anterior resection syndrome: a randomized clinical trial of a 5-HT3 receptor antagonist (ramosetron) in male patients with rectal cancer.

The British journal of surgery·2021
Same journal

Disrupted WWOX-MYC interplay impairs neurogenesis in human brain organoids.

Brain : a journal of neurology·2026
Same journal

SMPD4 deficiency disrupts indirect neurogenesis and neuronal migration in gyrencephalic cortex.

Brain : a journal of neurology·2026
Same journal

Retinal hyper-reflective foci link retinal and cortical pathology in paediatric multiple sclerosis.

Brain : a journal of neurology·2026
Same journal

Two scripts, two pathways: dorsal-ventral biases in post-stroke kana-kanji agraphia.

Brain : a journal of neurology·2026
Same journal

Blood cytotoxic natural killer-like CD8 + CD94+ T cells migrate to the brain and predict multiple sclerosis severity.

Brain : a journal of neurology·2026
Same journal

Time to reconsider risk for psychosis?

Brain : a journal of neurology·2026
See all related articles

New T2-weighted lesion volume changes, measured using difference imaging, are a more sensitive indicator of multiple sclerosis (MS) disease activity than traditional net lesion volume changes. This method better reflects total lesion activity and correlates more strongly with disease progression.

Area of Science:

  • Neuroimaging
  • Neurology
  • Radiology

Background:

  • Serial brain MRI is crucial for assessing multiple sclerosis (MS) disease activity and evaluating new therapies.
  • Traditional net T2-weighted lesion volume change underestimates total lesion activity by only considering the difference between new and resolved lesions.

Purpose of the Study:

  • To investigate if T2-weighted lesion difference imaging provides a more sensitive measure of MS disease activity compared to traditional net change.
  • To assess the correlation of new and net T2 lesion volumes with gadolinium-enhancing lesions and clinical progression.

Main Methods:

  • Generated T2-weighted difference images from serial registered MRI scans of 19 relapsing-remitting MS patients over 1 year.
  • Quantified separate volumes of new and resolving T2-weighted lesions.

Related Experiment Videos

  • Correlated T2 lesion volumes (new and net) with T1-weighted gadolinium-enhancing lesion volumes and clinical progression.

    • Main Results:

    • Mean new T2-weighted lesion volume was three times greater than mean net T2-weighted lesion volume change.
    • New T2 lesion volumes showed stronger correlations with T1 gadolinium-enhancing lesions and baseline T2 lesion volumes than net changes.
    • A trend suggested greater new T2 lesion volume in patients with sustained clinical progression, unlike net change.

    Conclusions:

    • T2-weighted lesion difference imaging offers a sensitive tool for monitoring MS disease activity.
    • This method allows for independent measurement of new and resolving lesions, potentially discriminating therapeutic effects on inflammation versus resolution/repair.