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Quantitative assay for epinephrine in dental anesthetic solutions by capillary electrophoresis
P Britz-Mckibbin1, A R Kranack, A Paprica
1Department of Chemistry, University of British Columbia, Vancouver, Canada.
The Analyst
|November 27, 1998
Abstract:
A simple and robust method for the separation and quantification of epinephrine in dental anesthetic solutions was developed. The method allows the direct injection of high salt solutions without sample pre-treatment. Large sample plugs (5.7% of the total capillary length) are used for epinephrine determination by selective analyte focusing in capillary electrophoresis. The concentration detection limit for epinephrine is about 5.0 x 10(-7) M (90 ng ml-1) with a commercial UV detector. The separation protocol was validated in terms of its precision, linearity, accuracy and specificity.