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[Lipoprotein(a) and lipids in chronic renal insufficiency and kidney transplant]
C A Ochoa-Sosa1, G Mondragón-Rodríguez, J Zamora-González
1Departamento de Endocrinología, Instituto Nacional de Cardiología Ignacio Chávez, México, D.F.
Insights
Patients undergoing hemodialysis show high rates of hypoalfalipoproteinemia and lipoprotein (a) excess. Renal transplantation may alter these lipid and lipoprotein profiles.
Area of Science:
- Nephrology
- Cardiovascular Medicine
- Clinical Chemistry
Background:
- Lipid and lipoprotein abnormalities are common in patients with chronic kidney disease.
- Understanding these abnormalities is crucial for managing cardiovascular risk in renal patients.
Purpose of the Study:
- To determine the prevalence of lipid and lipoprotein (a) disorders in patients undergoing hemodialysis and those who have received a renal transplant.
- To compare these prevalence rates with a control group from the general population.
Main Methods:
- A study involving 40 hemodialysis patients, 64 renal transplant recipients, and 77 age- and gender-matched controls from the general population.
- Analysis of lipid profiles and lipoprotein (a) levels in all participant groups.
Main Results:
- Hypoalfalipoproteinemia was the most frequent lipid disorder in hemodialysis patients, followed by excess lipoprotein (a).
- Renal transplant recipients exhibited the lowest prevalence of lipoprotein (a) excess and a higher rate of hypercholesterolemia compared to hemodialysis patients, similar to controls.
- Hypercholesterolemia was the least common disorder among hemodialysis patients.
Conclusions:
- Hypoalfalipoproteinemia is the predominant lipid abnormality in hemodialysis patients, contrasting with previous findings that often cited hypertriglyceridemia.
- Renal transplantation appears to modify lipid and lipoprotein profiles, reducing lipoprotein (a) excess and increasing hypercholesterolemia towards general population levels.
Objective:
To establish the prevalence of lipid and lipoprotein (a) abnormalities in patients under hemodialysis or who underwent renal transplantation.
Methods:
Forty dialyzed patients, 64 transplanted and a comparison group of 77 subjects of the general population paired by gender and age were studied.
Results:
The most prevalent disorder in the hemodialysis was hypoalfalipoproteinemia followed by Lp(a) excess while the least common disorder was hypercholesterolemia. The transplanted patients had the lowest prevalence of Lp(a) excess and a higher proportion of hypercholesterolemia when compared to hemodialysis patients but similar to that of controls.
Conclusion:
Our results confirmed some previous findings observations of others but differed in that hypoalfalipoproteinemia and not hypertriglyceridemia was the predominant abnormality in the hemodialysis patients.