[Lipoprotein(a) and lipids in chronic renal insufficiency and kidney transplant]

Related Experiment Video

Updated: Oct 27, 2026

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform
07:13

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform

Published on: April 12, 2021

C A Ochoa-Sosa1, G Mondragón-Rodríguez, J Zamora-González

  • 1Departamento de Endocrinología, Instituto Nacional de Cardiología Ignacio Chávez, México, D.F.

Revista De Investigacion Clinica; Organo Del Hospital De Enfermedades De La Nutricion
|November 27, 1998
PubMed

Insights

Patients undergoing hemodialysis show high rates of hypoalfalipoproteinemia and lipoprotein (a) excess. Renal transplantation may alter these lipid and lipoprotein profiles.

Area of Science:

  • Nephrology
  • Cardiovascular Medicine
  • Clinical Chemistry

Background:

  • Lipid and lipoprotein abnormalities are common in patients with chronic kidney disease.
  • Understanding these abnormalities is crucial for managing cardiovascular risk in renal patients.

Purpose of the Study:

  • To determine the prevalence of lipid and lipoprotein (a) disorders in patients undergoing hemodialysis and those who have received a renal transplant.
  • To compare these prevalence rates with a control group from the general population.

Main Methods:

  • A study involving 40 hemodialysis patients, 64 renal transplant recipients, and 77 age- and gender-matched controls from the general population.
  • Analysis of lipid profiles and lipoprotein (a) levels in all participant groups.

Main Results:

  • Hypoalfalipoproteinemia was the most frequent lipid disorder in hemodialysis patients, followed by excess lipoprotein (a).
  • Renal transplant recipients exhibited the lowest prevalence of lipoprotein (a) excess and a higher rate of hypercholesterolemia compared to hemodialysis patients, similar to controls.
  • Hypercholesterolemia was the least common disorder among hemodialysis patients.

Conclusions:

  • Hypoalfalipoproteinemia is the predominant lipid abnormality in hemodialysis patients, contrasting with previous findings that often cited hypertriglyceridemia.
  • Renal transplantation appears to modify lipid and lipoprotein profiles, reducing lipoprotein (a) excess and increasing hypercholesterolemia towards general population levels.
Abstract

More Related Videos

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice09:43

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...