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Related Experiment Videos

Concentrated cresol intoxication

M L Wu1, W J Tsai, C C Yang

  • 1Department of Medicine, Veterans General Hospital-Taipei, Taiwan, Taipei, ROC.

Veterinary and Human Toxicology
|November 27, 1998
PubMed
Summary
This summary is machine-generated.

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This case study highlights severe cresol poisoning from disinfectant ingestion. Despite massive doses and multiple organ complications, the patient recovered with intensive care, demonstrating cresol

Area of Science:

  • Toxicology
  • Clinical Case Study

Background:

  • Cresol, a common disinfectant, is known to cause significant toxicity.
  • Ingestion can lead to severe gastrointestinal, central nervous system, cardiovascular, renal, and hepatic damage.

Observation:

  • A 44-year-old male presented with unconsciousness after ingesting 300 ml of 50% cresol-soap solution.
  • Immediate interventions included endotracheal intubation, gastric lavage, and activated charcoal.
  • The patient developed dermal burns, esophageal/gastric erosion, pneumonia, metabolic acidosis, renal and liver impairment, leucocytosis, dark urine, acute renal failure, and hemolysis.

Findings:

  • Urine analysis revealed high levels of p-cresol, m-cresol, o-cresol, and phenol post-ingestion.
  • Despite ingesting a dose (150 g) far exceeding the reported lethal range (30-60 g), the patient survived.

Related Experiment Videos

  • Renal, pulmonary, and hematological effects were likely due to direct cresol and metabolite toxicity.

    • Implications:

    • This case underscores the potential for severe toxicity from cresol-based disinfectants.
    • Highlights the importance of prompt medical intervention and intensive supportive care in managing massive cresol poisoning.
    • Suggests that cresol toxicity can manifest with multi-organ involvement, including renal, pulmonary, and hematological systems.