[The Paget's disease--a gerontological study (author's transl)]

Area of Science:

• Gerontology
• Geriatrics
• Radiology
• Genetics

Background:

• Paget's disease of bone is a chronic condition.
• Prevalence is higher in older populations.
• Familial incidence is considered rare.

Purpose of the Study:

• To report interesting cases of Paget's disease.
• To highlight radiological and familial aspects.
• To discuss gerontological-geriatrical implications.

Main Methods:

• Screening of 1500 seemingly healthy patients.
• Diagnosis confirmed via radiological and laboratory examinations.
• Follow-up examinations after three years.

Main Results:

• Paget's disease incidence rate of 0.7% found in the study group.
• A family with three affected siblings (2 sisters, 1 brother) identified.
• Disease progression observed in two elderly women, with increased osteopathy and serum-alkaline-phosphatase activity.

Conclusions:

• Paget's disease can be present in asymptomatic individuals.
• Familial clustering of Paget's disease, though rare, warrants further investigation.
• Longitudinal monitoring reveals disease progression and biochemical changes in affected individuals.