[Automated analysis of changes in parameters of lung mechanics with alterations in breathing frequency, lung volume,...

Changes in parameters of respiratory mechanics with alteration in breathing frequency, lung volume and physical effort were determined in 23 subjects using automated data collection and data processing. Resistance R, Compliance C and work of breathing W show great dependence on breathing frequency and lung volume. An objective measuring of their changes during exercise requires a constant lung volume and a standardized breathing frequency. Parameters R and C and the maximal pressure amplitude DPM divided by the tidal volume VT show no significant alterations in several degrees of exercise. Work of breathing and work of breathing per tidal volume are enhanced significantly with increasing exercise. These parameters may estimate the mechanics of breathing better than R and C in patients with dyspnea during exercise.