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Effects of high-dose lisinopril-isosorbide dinitrate on severe mitral regurgitation and heart failure remodeling
A B Levine1, C Muller, T B Levine
1Michigan Institute for Heart Failure & Transplant Care, Farmington Hills 48336, USA.
The American Journal of Cardiology
|December 1, 1998
Abstract:
In long-term, 1-year follow-up, uptitration of angiotensin-converting enzyme inhibitor and nitrate therapy over established doses can further improve severe functional mitral regurgitation in patients with dilated cardiomyopathy due to a reversal of heart failure-related left ventricular remodeling. With marked left ventricular enlargement, >6.8 cm end-diastolic diameter, heart failure remodeling may be irreversible and resistant to further medical intervention.