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Rapid detection of dihydrocodeine by thermospray mass spectrometry
1Department of Legal Medicine, Kansai Medical University, Moriguchi, Japan.
Journal of Chromatography. B, Biomedical Sciences and Applications
|December 1, 1998
Abstract:
Rapid assay of dihydrocodeine (DHC) by thermospray mass spectrometry is explored. Liquid-liquid extractions of blood, urine and gastric contents were injected into a thermospray mass spectrometer, to which there was no column connected, and DHC was assayed by the flow injection method. The mass spectra of DHC under thermospray ionization and filament-on ionization modes consist of the MH+ ion of mlz 302 alone, which was clearly detected in the samples. Although DHC should be quantitated by gas chromatography-mass spectrometry, this method is applicable for rapid identification of DHC in biological materials.