Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Left ventricular restoring forces: modulation by heart rate and contractility

M M LeWinter1, J Fabian, S P Bell

  • 1Cardiology Unit, Fletcher Allen Health Care, Burlington, VT 05401, USA.

Basic Research in Cardiology
|December 2, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Acute cellular rejection in adult liver transplant recipients in Johannesburg, South Africa.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2025
Same author

Impact of donor <i>CYP3A5</i> genotype on pharmacokinetics of tacrolimus in South African paediatric liver transplant patients.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2024
Same author

A retrospective analysis of outcomes and complications of living- and deceased-donor split-liver transplantation in Johannesburg, South Africa.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2024
Same author

Wits Transplant Unit Annual Report 2022: Adult and paediatric liver transplantation.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2024
Same author

ABO-incompatible liver transplantation - exploring utilitarian solutions to restricted access and organ shortages: A single-centre experience from Johannesburg, South Africa.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2024
Same author

The paediatric liver transplant experience in Johannesburg, South Africa: A broad overview and update.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2024
Same journal

Molecular mechanisms of coronary microembolization-induced MINOCA.

Basic research in cardiology·2026
Same journal

Protection against postoperative atrial fibrillation via antiplatelet aggregation induced by remote ischemic preconditioning during off-pump coronary artery bypass grafting.

Basic research in cardiology·2026
Same journal

Peroxisomal catalase and plasmalogen biosynthesis protect from oxidative stress in Barth syndrome cardiomyopathy.

Basic research in cardiology·2026
Same journal

Bicuspid aortic valve stenosis is characterized by increased angiogenesis, inflammation, and a higher valvular-to-systemic calcification ratio than tricuspid aortic valve stenosis.

Basic research in cardiology·2026
Same journal

Myofilament-level effects of aficamten increase diastolic chamber volumes and maintain cardiac output through preserved length-dependent force generation in healthy rat and canine myocardium.

Basic research in cardiology·2026
Same journal

Functional rejuvenation of endothelial cell aging by transient reprogramming.

Basic research in cardiology·2026
See all related articles

Restoring forces normally aid left ventricular (LV) filling by suction. Increased contractility enhances these forces, but chronic heart failure significantly impairs them, potentially causing diastolic dysfunction.

Area of Science:

  • Cardiovascular Physiology
  • Cardiac Mechanics
  • Diastolic Function

Background:

  • Left ventricular (LV) filling is crucial for cardiac output.
  • Restoring forces (RFs) generated during contraction may contribute to LV filling.
  • The role of these forces in normal and pathological states requires further elucidation.

Purpose of the Study:

  • To characterize restoring forces (RFs) in the left ventricle (LV).
  • To investigate the impact of contractility and heart rate on RFs.
  • To determine the effect of chronic tachycardia heart failure on RFs and their contribution to diastolic function.

Main Methods:

  • Utilized a servomotor system in open-chest dogs to induce nonfilling diastoles.
  • Measured fully relaxed pressure (FRP) at end-systolic volume (ESV) to define the fully relaxed pressure-volume (FRPV) relation.

Related Experiment Videos

  • Administered systemic and intracoronary dobutamine to assess contractility effects; manipulated heart rate and studied chronic tachycardia heart failure models.

    • Main Results:

    • A negative fully relaxed pressure (FRP) indicates the presence of restoring forces (RFs) contributing to LV filling by suction.
    • Increased contractility (dobutamine) shifted the FRPV relation downward, signifying augmented RFs.
    • Chronic tachycardia heart failure markedly attenuated RFs, suggesting impaired diastolic filling capacity.

    Conclusions:

    • Restoring forces (RFs) are a normal physiological mechanism contributing to left ventricular (LV) filling.
    • Acute increases in contractility enhance RFs, while acute heart rate increases (within a specific range) do not.
    • Chronic tachycardia heart failure significantly diminishes RFs, potentially representing a key mechanism of diastolic dysfunction.