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Hepatitis E virus: complete genome sequence and phylogenetic analysis of a Nepali isolate
V Gouvea1, N Snellings, M J Popek
1Department of Virus Diseases, Walter Reed Army Institute of Research, Washington, DC 20307-5100, USA. imviver@microbio.ufrj.br
Virus Research
|December 2, 1998
Abstract:
The complete nucleotide sequence of the Nepali strain TK15/92 of hepatitis E (HEV) was determined. It showed the highest sequence homology with the Burmese B1 strain, but closer evolutionary relatedness to the Indian strains. Difficulties in reverse-transcribing and amplifying the hypervariable region in ORF1 suggested that strong secondary structures might be intrinsically responsible for the high mutational rate observed in this region of the HEV genome.