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Dilution and storage of botulinum toxin
1Department of Dermatology, UCLA School of Medicine, USA.
Summary
Determining the optimal dilution for botulinum toxin in cosmetic procedures remains debated. Most practitioners prefer a 2.5-3.0 ml dilution per vial, storing it for one week or less.
Area of Science:
- Aesthetics
- Dermatology
- Pharmacology
Background:
- Controversy exists regarding optimal botulinum toxin dilutions for cosmetic use, with recommendations varying from 1 ml to 10 ml per vial.
- Discussion also surrounds the choice of diluent (preserved vs. unpreserved saline) and post-dilution storage duration.
Purpose of the Study:
- To review existing literature and practitioner experience to clarify botulinum toxin dilution and storage practices.
- To address ongoing questions regarding the preparation of botulinum toxin for cosmetic applications.
Main Methods:
- Literature review of studies on botulinum toxin dilution and storage.
- Survey or compilation of clinical experience from practitioners in the field.
Main Results:
- Significant variation in dilutions used by physicians, often reflecting personal preference.
- A consensus appears to favor dilutions around 2.5 to 3.0 ml per vial.
- Approximately 75% of clinicians store diluted botulinum toxin for one week or less.
Conclusions:
- While dilution practices vary, a common range of 2.5-3.0 ml per vial is frequently employed.
- Short-term storage (≤1 week) is a prevalent practice among clinicians for diluted botulinum toxin.
