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Constipation: a common problem in patients with neurological abnormalities

G Bassotti1, R De Giorgio, V Stanghellini

  • 1Department of Clinical and Experimental Medicine, University of Perugia, Italy.

Italian Journal of Gastroenterology and Hepatology
|December 4, 1998
PubMed
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Neurological diseases frequently cause constipation by affecting the central, peripheral, or enteric nervous systems. Understanding these nerve-related causes is key to improving treatments for this common symptom.

Area of Science:

  • Neurogastroenterology
  • Neurology
  • Gastroenterology

Background:

  • Constipation is a common symptom in patients with various neurological disorders.
  • It can be the sole clinical sign or part of a larger syndrome.
  • Neurological conditions impact the central, peripheral, and enteric nervous systems, all influencing bowel function.

Purpose of the Study:

  • To review the neurological conditions associated with constipation.
  • To highlight the role of the nervous system in the pathophysiology of constipation.
  • To emphasize the need for further research into the mechanisms of neurogenic constipation.

Main Methods:

  • Literature review of studies on neurological diseases and constipation.
  • Analysis of neuropathophysiological mechanisms.

Related Experiment Videos

  • Categorization of causes based on the affected nervous system (central, peripheral, enteric).

    • Main Results:

    • Impairment of the enteric nervous system (developmental or acquired neuropathies) frequently causes constipation.
    • Peripheral nervous system disorders, such as diabetes and autonomic failure, are linked to constipation.
    • Central nervous system disorders (traumatic, degenerative, ischemic, neoplastic) can also lead to bowel dysfunction and constipation.

    Conclusions:

    • Constipation in neurological diseases stems from disruptions in the intrinsic (enteric) and extrinsic (central and peripheral) innervation of the gut.
    • Further elucidation of these pathophysiological mechanisms is crucial for developing effective treatments.
    • Understanding the neurogenic basis of constipation can improve patient outcomes.