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Granular-lattice (Avellino) corneal dystrophy

S Akiya1, H Takahashi, N Nakano

  • 1Department of Ophthalmology, University of Occupational and Environmental Health, Kitakyushu, Japan.

Ophthalmologica. Journal International D'Ophtalmologie. International Journal of Ophthalmology. Zeitschrift Fur Augenheilkunde
|December 5, 1998
PubMed
Summary

Granular-lattice corneal dystrophy, a rare condition combining granular and lattice patterns, was identified in Japanese patients. This rare dystrophy has a broader geographic distribution than previously thought.

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Area of Science:

  • Ophthalmology
  • Corneal Diseases
  • Histopathology

Background:

  • Granular-lattice (Avellino) corneal dystrophy is a rare inherited eye condition.
  • It presents with overlapping clinical features of both granular corneal dystrophy and lattice corneal dystrophy.
  • Previous reports on this condition are limited, with few documented cases.

Observation:

  • Histopathologic examination of a corneal button from a Japanese patient revealed features of both granular and lattice corneal dystrophy.
  • This patient underwent keratoplasty due to decreased vision, initially diagnosed with granular dystrophy.
  • Two additional Japanese patients presented clinically with combined granular and lattice corneal dystrophy features.

Findings:

  • The histopathology confirmed the co-existence of granular and lattice deposits in the cornea.

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  • Clinical observations supported the diagnosis of combined granular-lattice corneal dystrophy in multiple individuals.
  • The geographic distribution of granular-lattice corneal dystrophy appears wider than previously documented.

    • Implications:

    • This study expands the understanding of granular-lattice corneal dystrophy's presentation and pathology.
    • It suggests that the condition should not be exclusively associated with a specific geographic area.
    • Further research is warranted to elucidate the genetic and clinical spectrum of this rare dystrophy.