Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Adhesion molecules during immune response to exercise

H H Gabriel1, W Kindermann

  • 1Institute for Sports and Preventive Medicine, Faculty of Medicine, University of the Saarland, Saarbrücken, Germany. gabriel@rz.uni-sb.de

Canadian Journal of Physiology and Pharmacology
|December 5, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Limited benefit of Fatmax-test to derive training prescriptions.

International journal of sports medicine·2013
Same author

In reply.

Deutsches Arzteblatt international·2013
Same author

The right heart in athletes. Do we really have sufficient evidence for exercise-induced arrhythmogenic right ventricular cardiomyopathy?

Herzschrittmachertherapie & Elektrophysiologie·2012
Same author

[Influencing of the PSA concentration in serum by physical exercise (especially bicycle riding)].

Der Urologe. Ausg. A·2011
Same author

Differences in adaptations to 1 year of aerobic endurance training: individual patterns of nonresponse.

Scandinavian journal of medicine & science in sports·2010
Same author

Effects of one year aerobic endurance training on resting metabolic rate and exercise fat oxidation in previously untrained men and women. Metabolic endurance training adaptations.

International journal of sports medicine·2010
Same journal

Next-generation therapeutics and renaissance of legacy drugs targeting the endothelin system.

Canadian journal of physiology and pharmacology·2026
Same journal

Exploring the causal relationship between inflammatory cytokines and diabetic foot ulcer: A bidirectional Mendelian randomization and clinical validation study.

Canadian journal of physiology and pharmacology·2026
Same journal

TRPV1, Endocannabinoid, and Opioid Systems in Analgesia: Molecular Mechanisms and Drug Development Strategies.

Canadian journal of physiology and pharmacology·2026
Same journal

Association of stromal cell derived factor 1α and interferon-γ induced protein 10 with Fontan pathophysiology.

Canadian journal of physiology and pharmacology·2026
Same journal

Incretins for Type 2 Diabetes.

Canadian journal of physiology and pharmacology·2026
Same journal

Glucagon-like peptide 1 receptor agonists: anti-inflammatory effects in cardiovascular diseases.

Canadian journal of physiology and pharmacology·2026
See all related articles

Exercise alters leukocyte adhesion molecule avidity, influencing immune cell circulation. This impacts immune cell trafficking to inflammatory sites and blood cell counts during physical activity.

Area of Science:

  • Immunology
  • Cell Biology
  • Exercise Physiology

Background:

  • Cell-cell and cell-matrix interactions rely on adhesion molecules, crucial for leukocyte trafficking.
  • Leukocyte adhesion molecules (selectins, immunoglobulin superfamily, integrins) mediate initial tethering, firm attachment, and migration.
  • Inflammatory processes and hormonal signals modulate adhesion molecule function, directing leukocytes to inflammation sites.

Purpose of the Study:

  • To investigate how acute exercise influences leukocyte adhesion molecules and their role in immune cell redistribution.
  • To explore the mechanisms behind exercise-induced changes in leukocyte circulation, including sympathetic nervous system and HPA axis involvement.
  • To evaluate the contribution of adhesion molecules to altered leukocyte counts and trafficking during exercise.

Related Experiment Videos

Main Methods:

  • Analysis of leukocyte adhesion molecule function and expression.
  • Assessment of immune cell populations in blood circulation during and after exercise.
  • Investigation of hormonal and neural influences on leukocyte adhesion.

Main Results:

  • Acute exercise induces rapid changes in leukocyte circulation, increasing T and B lymphocytes, monocytes, and NK cells via demargination.
  • This demargination is likely mediated by beta 2 adrenergic receptors and altered adhesion molecule avidity.
  • Strenuous exercise leads to delayed neutrophilia and lymphocytopenia, attributed to altered circulation patterns potentially involving adhesion molecules.

Conclusions:

  • Exercise significantly impacts leukocyte adhesion and circulation, influencing immune surveillance and response.
  • Adhesion molecule avidity changes are key mediators of exercise-induced immune cell redistribution.
  • Further research is needed to fully elucidate the role of specific adhesion molecules in exercise immunology and resolve conflicting experimental findings.