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Related Experiment Videos

Tight and gap junctions in a vertebrate inner ear

J B Nadol, M J Mulroy, D A Goodenough

    The American Journal of Anatomy
    |November 1, 1976
    PubMed
    Summary

    The alligator lizard

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    Area of Science:

    • Auditory Neuroscience
    • Cell Biology
    • Histology

    Background:

    • The auditory organ's cellular structure is crucial for hearing.
    • Understanding cellular junctions in sensory organs provides insights into function.

    Purpose of the Study:

    • To investigate the types and locations of cellular junctions in the alligator lizard's auditory organ.
    • To correlate junctional structures with potential physiological functions.

    Main Methods:

    • Transmission electron microscopy was employed.
    • Methods distinguished between tight and gap junctions.

    Main Results:

    • Tight junctions form a barrier between endolymph and interstitial spaces.
    • Gap junctions are present between hair cells and supporting cells, and between supporting cells.
    • No tight junctions were found between perilymph and interstitial fluid.

    Conclusions:

    • Tight junction location suggests intercellular fluid composition resembles perilymph.
    • Gap junctions may mediate intracellular responses in supporting cells and electrical coupling between receptor cells.

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