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Cancer risk in diethylstilbestrol-exposed offspring
American Journal of Obstetrics and Gynecology
|November 1, 1976
Summary
Diethylstilbestrol (DES) exposure in utero is linked to vaginal adenosis and an increased risk of cervical and vaginal squamous intraepithelial neoplasia in young women. This study highlights the association between DES exposure and precancerous lesions.
Area of Science:
- Gynecology
- Obstetrics
- Oncology
Background:
- Diethylstilbestrol (DES) is a synthetic estrogen previously prescribed to prevent pregnancy complications.
- Intrauterine DES exposure has been associated with various reproductive tract abnormalities in female offspring.
- Vaginal adenosis, the presence of columnar epithelium in the vagina, is a known consequence of prenatal DES exposure.