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Related Experiment Videos

Recurrent hallucinations following ketamine

A Perel, J T Davidson

    Anaesthesia
    |October 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Ketamine anesthesia can cause rare, delayed hallucinations in children, similar to LSD flashbacks. Diazepam may help prevent these post-anesthesia perceptual side effects.

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    Area of Science:

    • Anesthesiology
    • Neuroscience
    • Psychiatry

    Background:

    • Ketamine is a widely used anesthetic agent.
    • Perceptual abnormalities are a known, albeit rare, side effect of ketamine.
    • Previous studies suggest benzodiazepines may mitigate these effects.

    Observation:

    • An 11-year-old boy experienced recurrent hallucinations for 5 days after ketamine anesthesia.
    • The patient had no prior adverse reactions to ketamine with diazepam supplementation.
    • This case highlights a delayed, recurring hallucinatory phenomenon.

    Findings:

    • Delayed recurrent hallucinations are a rare but serious adverse event following ketamine use.
    • The patient's symptoms resemble "flashback" phenomena associated with hallucinogenic drugs like LSD.

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  • Diazepam supplementation was effective in preventing similar reactions in the past.

    • Implications:

    • This case underscores the potential for delayed perceptual abnormalities after ketamine anesthesia in pediatric patients.
    • It reinforces the prophylactic value of diazepam in preventing post-ketamine-induced hallucinations.
    • Further research into the neurobiological mechanisms of ketamine-induced hallucinations and their prevention is warranted.