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Cellular mechanism of pulsatile LHRH release
1Department of Pediatrics, and Center for Neuroscience, University of Wisconsin-Madison, 1223 Capitol Court, Madison, Wisconsin, 53715-1299, USA.
General and Comparative Endocrinology
|December 9, 1998
Summary
The luteinizing hormone-releasing hormone (LHRH) system releases LHRH in pulses, crucial for reproduction. This review explores the concept of an internal LHRH pulse generator influenced by external factors.
Area of Science:
- Neuroendocrinology
- Reproductive Biology
Background:
- The hypothalamic luteinizing hormone-releasing hormone (LHRH) neuronal system exhibits pulsatile peptide release into the portal circulation.
- This pulsatile release is fundamental for normal reproductive function in mammals.
Purpose of the Study:
- To discuss the novel concept of an endogenous pulse-generating mechanism within LHRH neurons.
- To explore how this intrinsic mechanism is modulated by various neuronal and nonneuronal inputs.
Main Methods:
- This is a review article.
- Discussion of existing research and concepts regarding LHRH neuronal function.
Main Results:
- LHRH neurons are proposed to have an intrinsic ability to generate pulses.
- This endogenous rhythm is subject to modification by external regulatory signals.
Conclusions:
- The pulsatile release of LHRH is orchestrated by an internal mechanism within LHRH neurons.
- Reproductive function is maintained through the interplay of this endogenous rhythm and external modulatory inputs.