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Accommodation dynamics in aging rhesus monkeys

M A Croft1, P L Kaufman, K S Crawford

  • 1Department of Ophthalmology and Visual Sciences, Wisconsin Regional Primate Research Center, University of Wisconsin, Madison, Wisconsin 53792, USA.

The American Journal of Physiology
|December 9, 1998
PubMed
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Presbyopia, or age-related loss of eye focusing, is poorly understood. This study reveals age-related declines in ciliary body and lens dynamics, suggesting ciliary body dysfunction contributes to presbyopia.

Area of Science:

  • Ophthalmology
  • Gerontology
  • Physiology

Background:

  • Presbyopia is the age-related loss of the eye's ability to focus on near objects.
  • The underlying pathophysiology of presbyopia remains poorly understood.
  • Aging affects the dynamics of the eye's accommodative apparatus.

Purpose of the Study:

  • To investigate age-related changes in the dynamics of accommodation in rhesus monkeys.
  • To elucidate the roles of the ciliary body and lens in the development of presbyopia.

Main Methods:

  • Studied rhesus monkeys aged 4-24 years.
  • Utilized total iridectomy and midbrain electrode implantation for visualization and stimulation.
  • Employed real-time video techniques to quantify ciliary body and lens movements during accommodation and disaccommodation.

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Main Results:

  • In younger monkeys, accommodation involved biphasic ciliary body movement and monophasic lens movement.
  • With age, amplitude and velocity of ciliary body and lens movements declined during accommodation.
  • Age increased the latent period of movements and altered ciliary body movement to monophasic; disaccommodation velocity declined with age.

Conclusions:

  • Age-dependent decline in ciliary body movement amplitude and velocity suggests ciliary body dysfunction in presbyopia.
  • Age-related changes in lens movement may result from lens hardening or ciliary body motility changes.
  • Understanding these age-related dynamics is crucial for addressing presbyopia.