Related Experiment Video

Updated: Jul 31, 2026

Drug-induced Sensitization of Adenylyl Cyclase: Assay Streamlining and Miniaturization for Small Molecule and siRNA Screening Applications
09:39

Drug-induced Sensitization of Adenylyl Cyclase: Assay Streamlining and Miniaturization for Small Molecule and siRNA Screening Applications

Published on: January 27, 2014

An improved and updated version of the compact procedure for the evaluation of P450-mediated chemical activation

D F Lewis1, C Ioannides, D V Parke

  • 1School of Biological Sciences, University of Surrey, Guildford, UK.

Drug Metabolism Reviews
|December 9, 1998
PubMed
Abstract

No abstract available in PubMed .

More Related Videos

Formation of Covalent DNA Adducts by Enzymatically Activated Carcinogens and Drugs In Vitro and Their Determination by 32P-postlabeling
09:33

Formation of Covalent DNA Adducts by Enzymatically Activated Carcinogens and Drugs In Vitro and Their Determination by 32P-postlabeling

Published on: March 20, 2018

Scaled-Up Preparation of an Intermediate of Upatinib, ACT051-3
08:36

Scaled-Up Preparation of an Intermediate of Upatinib, ACT051-3

Published on: April 7, 2023

Related Experiment Videos

Last Updated: Jul 31, 2026

Drug-induced Sensitization of Adenylyl Cyclase: Assay Streamlining and Miniaturization for Small Molecule and siRNA Screening Applications
09:39

Drug-induced Sensitization of Adenylyl Cyclase: Assay Streamlining and Miniaturization for Small Molecule and siRNA Screening Applications

Published on: January 27, 2014

Formation of Covalent DNA Adducts by Enzymatically Activated Carcinogens and Drugs In Vitro and Their Determination by 32P-postlabeling
09:33

Formation of Covalent DNA Adducts by Enzymatically Activated Carcinogens and Drugs In Vitro and Their Determination by 32P-postlabeling

Published on: March 20, 2018

Scaled-Up Preparation of an Intermediate of Upatinib, ACT051-3
08:36

Scaled-Up Preparation of an Intermediate of Upatinib, ACT051-3

Published on: April 7, 2023

Related Concept Videos

Catalysis02:50

Catalysis

The presence of a catalyst affects the rate of a chemical reaction. A catalyst is a substance that can increase the reaction rate without being consumed during the process. A basic comprehension of a catalysts’ role during chemical reactions can be understood from the concept of reaction mechanisms and energy diagrams.
Drug Metabolism: Phase I Reactions01:17

Drug Metabolism: Phase I Reactions

A phase I reaction is a biochemical process that introduces a functionally reactive polar group to a substance. This transformation predominantly occurs in the liver, facilitated by the cytochrome P450 system of hemoproteins situated in the lipophilic endoplasmic reticulum of cells. The metabolite generated through this process can have varying polarities. If it is sufficiently polar, it can be easily excreted in the urine due to its water compatibility. However, if the metabolite is nonpolar,...

Articles linked to this work by shared authors, journal, and citation graph.

An improved method to estimate ultrasonic absorption in agar-based gel phantom using thermocouples and MR thermometry.

Ultrasonics·2020

PP171. Hospitalized preterm mild preeclamptics: Is there a difference in outcomes between isolated or superimposed disease?

Pregnancy hypertension·2015

Xenobiotic-metabolizing enzyme systems and aging.

Methods in molecular medicine·2012

Modulation of hepatic cytochrome P450 activity and carcinogen bioactivation by black and decaffeinated black tea.

Environmental toxicology and pharmacology·2011

Dissimilar tcr v-Beta frequencies in til from different sites of the same tumor.

International journal of oncology·2011

Common tcr-Beta chain rearrangements in short-term cultured lymphocytes infiltrating ovarian-tumors.

International journal of oncology·2011

Reprogramming of hepatic drug metabolism following early-life xenobiotic exposure: insights from nuclear receptor pathways.

Drug metabolism reviews·2026

Metabolic pharmacology of anthelmintic drugs targeting mitochondrial fumarate reductase in neurocysticercosis.

Drug metabolism reviews·2026

Metabolism-driven hepatotoxicity of 5-fluorouracil: molecular mechanisms and future therapeutic directions.

Drug metabolism reviews·2026

SAR and mechanistic pathways of oxadiazole derivatives: targeting enzymes for antidiabetic therapy.

Drug metabolism reviews·2026

Bioactivation and reactivity research advances - 2025 year in review.

Drug metabolism reviews·2026

Humanized mouse models for drug metabolism and drug transport: a systematic review.

Drug metabolism reviews·2026

Evaluation of the Protective Effect of a Well-Characterized n-Hexane Extract of Black Soldier Fly Larvae (Hermetia illucens) Against Acrylamide-Induced Testicular Damage in Male Rats: A Histopathological, Oxidative Stress, Inflammatory, and Molecular Study.

Iranian journal of pharmaceutical research : IJPR·2026

Local triamcinolone acetonide injection for the prevention of pharyngeal deformity following endoscopic submucosal dissection of superficial pharyngeal neoplasms.

Esophagus : official journal of the Japan Esophageal Society·2026

Designing artificial cofactors and their enzymes together.

Trends in biotechnology·2026

A Novel 2-Hz Coronary Intravascular Lithotripsy Catheter for Calcified Coronary Artery Disease: One-Year Outcomes of the DISRUPT CAD Duo Trial.

The American journal of cardiology·2026

Steering ecological interactions in microbial chain elongation: functions and impacts of carbon- and iron-based materials.

Biotechnology advances·2026

The innate immune adaptor protein STING modulates lipid metabolism in an AMPK-dependent manner in Tribolium castaneum.

Insect biochemistry and molecular biology·2026
See all related articles
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies
Jove
Visualize
Contact Us