[Correlation analysis of the venous return effect on the central venous pressure during transitional circulation...

A fully computerized control of systemic circulation based on negative bio-technical feedback between cardiovascular system and automated external control enabled one to allocate contribution of venous return in the shifts of the total central venous pressure in cats. Using adrenaline and noradrenaline administration, shifts in the venous return were shown to induce the main portion (over 50%) of the total central venous pressure changes. Correlation analysis revealed a highly significant (p < 0.01) linear correlation between the maximal shifts of these two parameters of the systemic circulation. The findings suggest a close connection between the venous return changes and central venous pressure during pressure responses in the systemic circulation.