[Lupus erithematosus and kidney disease in a three year old girl (author's transl)]

A case of systemic lupus erythematosus in a 3-year-old girl is presented. The diagnosis is based on the systemic involvement and repeated positivity for anti-DNA antibodies and L.E. phenomenon. A renal biopsy under optic and electron microscopy, disclosed diffuse glomerular cell proliferation and electron-dense deposits along the basal membrane. Increased basement membrane-like material is present between mesangial cells. Hematoxilinic bodies or virus-like inclusions were not found. Treatment with corticosteroids gave good results. A trial with antimalarial drugs had to be discontinued due to gastric intolerance and alopecia.