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Perspective: edible vaccines--a concept coming of age

T S Mor1, M A Gómez-Lim, K E Palmer

  • 1Boyce Thompson Institute for Plant Research, Ithaca, NY 14853-1801, USA.

Trends in Microbiology
|December 10, 1998
PubMed

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Microorganisms in Medicine and Therapeutics

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Vaccine Production

Vaccine production involves a sequence of upstream and downstream processes to generate a safe and effective immunological product. It begins with cultivating microorganisms, such as viruses or bacteria, to obtain antigenic material. For viral vaccines, mammalian host cells are grown in bioreactors and subsequently infected with the target virus. The virus replicates within the host cells, which are lysed to release viral particles. This lysate is then clarified through filtration or...