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The EMBL Nucleotide Sequence Database

G Stoesser1, M A Tuli, R Lopez

  • 1EMBL Outstation-The European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK. stoesser@ebi.ac.uk

Nucleic Acids Research
|December 10, 1998
PubMed
Summary
This summary is machine-generated.

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The EMBL Nucleotide Sequence Database is Europe's main resource for DNA and RNA sequences, updated quarterly. It offers network services and tools for sequence similarity searching, aiding biological research.

Area of Science:

  • Bioinformatics
  • Genomics
  • Molecular Biology

Background:

  • The EMBL Nucleotide Sequence Database serves as Europe's central repository for nucleotide sequences.
  • It aggregates data from diverse sources, including individual researchers, genome projects, and patent applications.

Purpose of the Study:

  • To describe the EMBL Nucleotide Sequence Database as a key resource for biological research.
  • To outline the data submission, maintenance, and distribution processes.
  • To highlight the accessibility and utility of the database for sequence analysis.

Main Methods:

  • Data collection through direct submissions (e.g., Webin) and automated pipelines (e.g., from genome centers and EPO).
  • Collaborative maintenance and distribution with DDBJ and GenBank.

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  • Quarterly database releases and continuous network services for up-to-date access.

    • Main Results:

    • The database provides a comprehensive and current collection of nucleotide sequences.
    • Network services, including the Sequence Retrieval System (SRS), facilitate integrated access to molecular biology data.
    • Tools like BLAST and FASTA enable efficient sequence similarity searching.

    Conclusions:

    • The EMBL Nucleotide Sequence Database is a vital, collaboratively maintained resource for the European scientific community.
    • Its integrated data access and analysis tools support advancements in genomics and molecular biology.
    • Continuous updates and diverse access methods ensure its relevance and utility for researchers worldwide.