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Vertebrate MitBASE: a specialised database on vertebrate mitochondrial DNA sequences
A Carone1, S B Malladi, M Attimonelli
1Dipartimento di Biochimica e Biologia Molecolare, Universita' degli studi di Bari. Via E. Orabona 4, 70126 Bari, Italy and EBI, Hinxton Hall, Hinxton, Cambridge, UK.
Nucleic Acids Research
|December 10, 1998
Summary
Vertebrate MitBASE centralizes vertebrate mitochondrial DNA data from multiple sources. This specialized database offers integrated variant analysis and user-friendly access to comprehensive mitochondrial genome information.
Area of Science:
- Bioinformatics
- Genomics
- Molecular Biology
Background:
- Mitochondrial DNA (mtDNA) research is crucial for understanding evolution and disease.
- Existing primary databases lack comprehensive integration and variant analysis for vertebrate mtDNA.
- A centralized, curated resource is needed for efficient access to vertebrate mtDNA data.
Purpose of the Study:
- To introduce Vertebrate MitBASE, a specialized database for vertebrate mitochondrial DNA.
- To provide integrated information, including variant sequences, linked to reference sequences.
- To offer a user-friendly interface for accessing and analyzing vertebrate mtDNA data.
Main Methods:
- Collection and integration of vertebrate mtDNA entries from primary databases.
- Revision and updating of data with information from scientific literature.
- Analysis and alignment of variant sequences, linked to reference sequences.
- Development of a flexible WWW interface with a retrieval system for non-expert users.
Main Results:
- Vertebrate MitBASE consolidates diverse vertebrate mtDNA data.
- Variant sequences are analyzed, aligned, and linked to reference sequences.
- The database provides integrated information not found in primary sources.
- A user-friendly interface facilitates data retrieval for various users.
Conclusions:
- Vertebrate MitBASE serves as a valuable, centralized resource for vertebrate mitochondrial genomics.
- The database enhances accessibility and utility of mitochondrial DNA information.
- It supports research in evolutionary biology, population genetics, and disease studies.