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Related Experiment Videos

The tmRNA website

K P Williams1

  • 1Department of Biology, Jordan Hall A411, Indiana University, Bloomington, IN 47405, USA. kwilliam@bio.indiana.edu

Nucleic Acids Research
|December 10, 1998
PubMed
Summary
This summary is machine-generated.

Transfer messenger RNA (tmRNA) facilitates protein quality control by tagging truncated proteins for degradation. The tmRNA website now includes sequences from 46 species, enhancing phylogenetic analysis.

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Area of Science:

  • Molecular Biology
  • Bacteriology
  • Genetics

Background:

  • Transfer messenger RNA (tmRNA), also known as 10Sa RNA, plays a crucial role in the trans-translation process.
  • Trans-translation involves tagging aberrant, short-stalled protein products from damaged messenger RNA (mRNA) with a peptide tag for subsequent proteolysis.
  • The tmRNA website was initially created to support phylogenetic studies of tmRNA structure and function.

Purpose of the Study:

  • To expand the tmRNA database with newly identified sequences.
  • To provide updated resources for phylogenetic analysis of tmRNA.
  • To facilitate the identification and study of tmRNA across diverse bacterial species and chloroplasts.

Main Methods:

  • Systematic identification and sequencing of tmRNA from various bacterial phyla and chloroplasts.

Related Experiment Videos

  • Database compilation and curation of identified tmRNA sequences.
  • Development of provisional sequence alignments and prediction of proteolysis tag sequences.

    • Main Results:

    • The tmRNA database now encompasses sequences from 46 species across 10 bacterial phyla and chloroplasts.
    • Three partial tmRNA sequences have been completed, and 13 additional species have been identified since the last update.
    • Provisional sequence alignments and predicted proteolysis tag sequences are now available.

    Conclusions:

    • The expanded tmRNA database provides a valuable resource for understanding tmRNA evolution and function.
    • The updated website facilitates research in bacterial genetics and molecular biology.
    • The resource aids in the discovery and analysis of tmRNA sequences in diverse organisms.