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Related Experiment Videos

The guide RNA database (3.0)

S Hinz1, H U Göringer

  • 1Laboratorium für Molekulare Biologie, Genzentrum der Ludwig-Maximilians-Universität München,82152 Martinsried, Germany.

Nucleic Acids Research
|December 10, 1998
PubMed
Summary
This summary is machine-generated.

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Kinetoplastid mitochondrial RNA editing is regulated by guide RNAs. A new database compiles 254 guide RNA sequences from 11 organisms, aiding research.

Area of Science:

  • Molecular Biology
  • Genetics
  • Bioinformatics

Background:

  • Mitochondrial RNA editing in kinetoplastids is a unique post-transcriptional process.
  • This process is essential for producing functional mitochondrial transcripts.
  • Small trans-acting RNA molecules, known as guide RNAs, are critical regulators.

Purpose of the Study:

  • To create a centralized repository for guide RNA sequences.
  • To facilitate research on RNA editing mechanisms in kinetoplastids.
  • To provide comprehensive data including structural and genetic information.

Main Methods:

  • Compilation of published guide RNA sequences.
  • Inclusion of data on RNA secondary and tertiary structures.
  • Annotation of gene localization and relevant literature.

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Main Results:

  • The Guide RNA Database contains 254 entries.
  • Data spans 11 different kinetoplastid organisms.
  • Includes structural models, gene localization, and literature citations.

Conclusions:

  • The Guide RNA Database serves as a valuable resource for studying kinetoplastid RNA editing.
  • Centralized data promotes further investigation into RNA editing pathways.
  • Accessibility via the World Wide Web enhances its utility for the scientific community.