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The RNA Modification Database: 1999 update

J Rozenski1, P F Crain, J A McCloskey

  • 1Department of Medicinal Chemistry and Department of Biochemistry, University of Utah, 30 S. 2000 East,Salt Lake City, UT 84112-5820, USA.

Nucleic Acids Research
|December 10, 1998
PubMed
Summary
This summary is machine-generated.

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The RNA Modification Database lists naturally modified nucleosides in RNA, detailing their structures, occurrence, and origins. It now features enhanced search capabilities and expanded content on tmRNA modifications.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Bioinformatics

Background:

  • Naturally occurring nucleoside modifications are crucial for RNA function and stability.
  • A centralized resource is needed to catalog these diverse modifications.
  • Existing databases may lack comprehensive data or user-friendly search functionalities.

Purpose of the Study:

  • To present the RNA Modification Database as a comprehensive resource for naturally modified nucleosides in RNA.
  • To detail the information included for each modified nucleoside.
  • To highlight new features enhancing database utility.

Main Methods:

  • Compilation of data on chemical structure, nomenclature, RNA types, phylogenetic distribution, and literature citations.
  • Implementation of search functionalities for names and substructural features.

Related Experiment Videos

  • Inclusion of data on transfer-messenger RNA (tmRNA) modifications and links to related resources.

    • Main Results:

    • The database provides detailed information for numerous modified nucleosides.
    • Search capabilities allow for efficient retrieval of specific modifications.
    • The database now includes modifications found in tmRNA, expanding its scope.

    Conclusions:

    • The RNA Modification Database serves as a vital, up-to-date resource for researchers studying RNA modifications.
    • Enhanced search features and expanded content improve accessibility and utility for the scientific community.
    • The database facilitates research in molecular biology, biochemistry, and related fields.