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Related Experiment Videos

PRINTS prepares for the new millennium

T K Attwood1, D R Flower, A P Lewis

  • 1School of Biological Sciences, University of Manchester, Manchester M13 9PT, UK. attwood@biochemistry.ucl.ac.uk

Nucleic Acids Research
|December 10, 1998
PubMed
Summary
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Protein fingerprints (PRINTS) use motif groups for reliable protein family identification. Recent updates enhance this diagnostic resource with new search tools and database integration for improved genome analysis.

Area of Science:

  • Bioinformatics
  • Computational Biology
  • Protein Science

Background:

  • PRINTS is a curated collection of protein fingerprints.
  • Fingerprints utilize conserved motif groups to define protein family signatures.
  • This approach enhances diagnostic reliability compared to single-motif methods.

Purpose of the Study:

  • To describe the PRINTS database and its recent enhancements.
  • To highlight the utility of protein fingerprints in bioinformatics.
  • To outline ongoing efforts for database improvement and integration.

Main Methods:

  • Development and storage of protein fingerprints, comprising groups of motifs.
  • Implementation of a BLAST server and efficient fingerprint search software.

Related Experiment Videos

  • Integration with other protein pattern databases (PROSITE, Pfam, etc.) for the InterPro project.

    • Main Results:

    • The PRINTS database (v20.0) contains approximately 1000 fingerprints and 5700 motifs.
    • Enhanced search software provides improved statistics for match reliability.
    • Recent developments focus on automated maintenance and data management.

    Conclusions:

    • PRINTS serves as a valuable diagnostic resource for protein family identification.
    • Ongoing development aims to unify protein pattern databases and improve genome analysis tools.
    • The integration within the InterPro project signifies a move towards standardized protein family analysis.