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New mouse model for dengue virus vaccine testing

A J Johnson1, J T Roehrig

  • 1Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, United States Department of Health and Human Services, Fort Collins, Colorado 80522, USA. ajj1@ckc.goN

Journal of Virology
|December 16, 1998
PubMed
Summary

Researchers developed a new small animal model for dengue virus vaccine testing. AG129 mice lacking interferon functions are susceptible to dengue, proving useful for vaccine trials.

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Area of Science:

  • Virology
  • Immunology
  • Animal Models

Background:

  • Dengue virus (DEN) vaccine development is hindered by the absence of suitable small animal models.
  • Interferon (IFN) is implicated in the human immune response to DEN virus.

Purpose of the Study:

  • To evaluate interferon-deficient AG129 mice as a small animal model for DEN virus vaccine efficacy studies.

Main Methods:

  • AG129 mice, lacking alpha/beta interferon and gamma interferon receptor genes, were infected with a mouse-adapted DEN 2 virus.
  • Survival rates and protection were assessed in infected mice, including those receiving immunized or antibody treatments.

Main Results:

  • Intraperitoneal administration of DEN 2 virus proved uniformly lethal in AG129 mice across all age groups.

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  • Vaccine immunization conferred protection against DEN virus challenge.
  • Passive transfer of anti-DEN polyclonal antibodies increased survival times.

    • Conclusions:

    • AG129 mice lacking interferon functions represent a promising and reliable small animal model for evaluating DEN virus vaccines.
    • This model facilitates the advancement of DEN virus vaccine research and development.