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Related Experiment Videos

[A new hydroxyethyl starch for volume replacement: Elohes 6%]

J Medel1, J F Baron

  • 1Servicio Nadia du Bouchet de Anestesia y Reanimación, Hospital Broussais, París, Francia.

Revista Espanola De Anestesiologia Y Reanimacion
|December 16, 1998
PubMed
Summary

Medium molecular weight hydroxyethylstarches (HES) offer effective plasma volume expansion comparable to albumin with fewer side effects. These colloids are recommended for anesthesia and intensive care, balancing efficacy with safety.

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Area of Science:

  • Anesthesiology and Perioperative Medicine
  • Critical Care Medicine
  • Pharmacology

Context:

  • Plasma volume expansion solutions are crucial in managing shock, burns, and surgical patients.
  • Traditional solutions like human albumin are costly, while dextrans and gelatins have limitations.
  • Hydroxyethylstarches (HES) represent a newer class of colloids with varying properties.

Purpose:

  • To evaluate the efficacy and safety of medium molecular weight hydroxyethylstarches (HES), specifically Elohes 6% (6% HES 200/0.62), as a plasma volume expander.
  • To compare HES performance against human albumin and other available colloids in clinical settings.
  • To assess the side effect profile, including anaphylactoid reactions, coagulation effects, and renal impact.

Summary:

  • Medium molecular weight HES, such as Elohes 6%, demonstrate volume expansion comparable to human albumin in diverse clinical scenarios like cardiac surgery and shock.

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  • HES exhibit a low frequency of anaphylactoid reactions, similar to albumin.
  • Coagulation effects are generally minimal when recommended doses are adhered to, though prolonged administration may affect Factor VIII/von Willebrand complex. Renal effects remain under investigation.

    • Impact:

    • Medium molecular weight HES provide a cost-effective and safe alternative to human albumin for plasma volume expansion.
    • Their favorable profile supports their use in anesthesia and postoperative intensive care, potentially improving patient outcomes.
    • Further research into renal effects is warranted to fully elucidate the safety profile of HES.