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Autonomic neuropathies

P A Low1

  • 1Mayo Medical School, Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA.

Current Opinion in Neurology
|December 16, 1998
PubMed
Summary
This summary is machine-generated.

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Autonomic neuropathy can cause various syndromes like POTS and chronic fatigue. While some forms are treatable with interventions like liver transplants or medications, their specific causes and antibody targets require further investigation.

Area of Science:

  • Neurology
  • Autonomic Nervous System Disorders

Background:

  • Autonomic neuropathy is linked to syndromes such as postural tachycardia syndrome, pseudo-obstruction, heat intolerance, and chronic fatigue syndrome.
  • Autonomic dysfunction negatively impacts prognosis in diabetic patients.
  • Antibodies targeting autonomic structures are prevalent in diabetes, but their precise roles remain unclear.

Purpose of the Study:

  • To explore the role of autonomic neuropathy in specific clinical syndromes.
  • To discuss the implications of autonomic failure in diabetes.
  • To review current and potential treatments for autonomic neuropathies.

Main Methods:

  • Literature review of studies on autonomic neuropathy and related syndromes.
  • Analysis of the role of antibodies in diabetic autonomic neuropathy.
Keywords:
NASA Discipline CardiopulmonaryNon-NASA Center

Related Experiment Videos

  • Examination of treatment outcomes for various autonomic neuropathies.

    • Main Results:

    • Autonomic neuropathy is implicated in postural tachycardia syndrome, pseudo-obstruction, heat intolerance, and chronic fatigue syndrome.
    • Autonomic failure exacerbates the prognosis of diabetes.
    • Familial amyloid polyneuropathy may benefit from liver transplantation; acute panautonomic neuropathy has shown anecdotal response to intravenous gamma globulin; orthostatic hypotension may improve with erythropoietin or midodrine.

    Conclusions:

    • Autonomic neuropathy is a significant factor in several distinct clinical presentations.
    • Targeted treatments offer potential for managing specific autonomic neuropathies, including those in diabetic patients.
    • Further research is needed to elucidate antibody specificities and optimize therapeutic strategies for autonomic nervous system disorders.