[Physiological and adaptive value of Na+,K+-ATPase isoenzymes]

A current state of the researches related to functional specificity of the Na+, K(+)-ATP-ase isozymes determined by their catalytic properties, individual sensitivity to regulation by hormones and other endogenic substances and to membrane structural disorders has been reviewed to clarify the physiological expediency of the Na+, K(+)-ATP-ase isoforms. The data on isozymes expression in brain in the ontogenesis, their individual sensitivity to ouabain and peculiarities of the membrane properties are considered. The adaptive significance of the Na+, K(+)-ATP-ase isozymes in expansion of tissue compensatory resources at some physiological and pathological states of organism is supposed.